Impact of a strong fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer

Impact of a strong fiber, low-fat diet intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer

ABSTRACT

OBJECTIVE: The power of the tests for the intervention are to examine whether food postdiagnosis May change will affect the recurrence of breast cancer and of survival. A mechanism is a possible impact on the reproduction of steroid hormones.

PARTICIPANTS AND METHODS: The serum concentrations of reproductive steroid hormones were used for the intake and 1 year 291 women with a history of breast cancer was demonstrated in a randomized, controlled intervention process food. Goals of nutrition for the intervention group were the increase in fiber, fruits and vegetables and reducing the intake of fat. Estradiol bioavailable estradiol, estrone, estrone sulfate, Androstendion, testosterone, dehydroepiandrosterone sulfate, follicle stimulating hormone and globulin between the sex hormones were.
RESULTS: The intervention (although not from) the group is supported by a significantly lower fat content (21% vs. 28%) and an increase in the intake of dietary fiber (29 g / dv 22 g / d) up to 1 year follow-up ( P <.001). Weight loss is not in one or the other group. A significant difference in the change in concentration of estradiol biological basis for 1 year in the intervention (-13 pmol / L) compared with (3 pmol / L) in the group observed (p <.05). Changes in the fiber (not fat) for the admission was significantly and independently related to the change in serum levels of bioavailable estradiol (P <.01) and total estradiol (p <.05) concentrations. CONCLUSION: The results of this study show that high fiber, low-fat intervention in conjunction with a decrease in serum concentrations of estradiol bioavailability in women with breast cancer, most of which are no signs of weight loss. Increase the intake of dietary fiber, regardless of the lowering of serum levels of estradiol.

INTRODUCTION

Breast cancer represents 31% of all cancers and 15% of cancer deaths among women in the United States. Due to a reduction in deaths associated with the incidence, the number of women in the U.S., the survivors of breast cancer is increasing. Despite 5 years to promote the survival of women diagnosed with breast cancer have completed their initial processing remain cancer risk again, and at higher risk of new breast cancer primary and premature deaths that women suffering from breast cancer.

A possible link between diet and breast cancer risk for the primary school was a great interest in science and research in recent decades. Fewer data on the relationship between diet and the risk for or survivor's pension after the diagnosis of breast cancer has been reviewed and reported.4 but the results of observational studies suggest that the dietary influence on the prognosis of May and the diet of the examination are to be used, postdiagnosis whether the diet can increase the risk of a change to the recurrence of cancer and improve overall survival.

There are several mechanisms by which the composition of the diet in May to influence the overall survival after diagnosis of breast cancer after initial treatment. One mechanism is through an effect on the reproduction of steroid hormones. An important feature of the proliferation of normal mammalian cells and the differentiation is the ability of these cells to respond to estrogen in the cell and mitogen factors influencing the growth of regulation in all cell types. And by promoting the reduction of estrogen after the diagnosis of breast cancer is a management strategy. In fact, the therapy has become one of the most effective treatments for the management of the endocrine response to breast cancer, representing about two-thirds of the cases, as in randomized clinical trials.

Because he suspected that the adoption of a low-fat diet in May reduce the serum concentrations of estrogens, the effects of reducing dietary fats on the serum levels of estrogens has been demonstrated in a series of studies on short-term, healthy diet and nutrition, and targeted at women after préménopause menopause, as summarized in a meta-analysis by Wu et al. But other factors also confusion about the interpretation of these studies, including the loss of weight and increase the contribution of fibers. An energy and weight loss should be the reduction of serum concentrations of hormones Gonadenfunktion, regardless of diet. The feed and studies have shown that dietary fiber reduce estrogen May movement independent of the concentration, so that the specificity of the effect of changes in intake of fat (as opposed to other changes in the diet) is not bad. Foods high fiber, such as cereals and vegetables are rich in resources to other parts of the diet, the metabolism, May Influence of estrogen (eg, indoles, isoflavones). The short duration of the studies on the modification of the diet of estrogen in the serum (usually less than 5 months) for women in good health is another characteristic limit. Regulatory mechanisms homéostatique May amended so that the adjustment of the height of the biosynthesis and metabolism or loss of stool, so that the serum levels back to their original levels over time, what the clinical significance of long-term.

The impact of a low-fat intervention on serum concentrations of estrogens have been divided into two groups of postmenopausal women with breast cancer. In 19 of the women who participate in the intervention in the food for the women in the study (WINS) feasibility study, estradiol (not complete or estrogen estrone) decreased by 6 months, in conjunction with a reduction in the intake of fats (34% to 22% of calories). However, the weight was increased by an average of 3.5% during this period, and no control group was at the same time. In the second sub-group of the 93 participants of WINS, the changes in the average serum concentration of estradiol or estrone were not observed in the intervention or control group after 18 months of follow-up.

The objective of this study was to investigate the effects of a high vegetable, high fiber, low-fat intervention on serum concentrations of reproductive steroid hormones in women with a history of breast cancer in their first year of participation in a clinical trial of the impact of the change of diet on disease relapse and survival. Another objective of the study was to determine the relationship between changes in intakes of dietary fiber and fat and changes in the bioavailability of estradiol and total serum concentrations of estradiol and 1 year for those participants in the study.